ChemBK
  • Home
  • Product Category

APD 356

Lorcaserin

CAS: 616202-92-7

Molecular Formula: C11H14ClN

  1. Home
  2. Product Category
  3. other
  4. other
  5. APD 356

APD 356 - Names and Identifiers

Name Lorcaserin
Synonyms Ar-10a
APD356
AR-10A
Apd356
Apd 356
Apd-356
APD 356
APD-356
Unii-637E494o0z
(R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
(1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
(1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-Benzazepine
CAS 616202-92-7
EINECS 809-254-4
InChI InChI=1/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1

APD 356 - Physico-chemical Properties

Molecular FormulaC11H14ClN
Molar Mass195.69
Density1.075
Boling Point288 ºC
Flash Point128 ºC
Solubility Chloroform (Slightly), Methanol (Slightly)
Vapor Presure0.002mmHg at 25°C
AppearanceLight Beige to Beige Semi-Solid
pKa9.99±0.40(Predicted)
Storage Condition-20°C Freezer
StabilityHygroscopic
Refractive Index1.527

APD 356 - Reference Information

slimming drug lorcaserin (lorcaserin) is a new type of drug for the treatment of obesity, belonging to an oral and effective selective serotonin 2C receptor agonist. lorcaserin hydrochloride (lorcaserin hydrochloride,BelviqTM) was successfully developed by Arena Company of the United States and was approved by FDA for listing on June 27, 2012, adjunctive therapy on a low-calorie diet and exercise basis for overweight adults who are obese or have at least one weight-related complication. Clinical studies have shown that the drug can effectively reduce the weight of obese and overweight patients, improve obesity-related metabolic indicators, and is well tolerated. The affinity of lorcaserin for 5-HT2c is 100 times higher than that of 5-HT2B (risk of valvular heart disease), and its safety is good. It is the first weight loss drug approved by FDA after 1999. After one year of treatment with lorcaserin, the average weight loss ranged from 3% to 3.7%.
mechanism of action lorcaserin is a serotonin 2C(5-HT2C) receptor selective serotonin agonist, 5-HT2C receptors Almost only distributed in the brain. The activation of this receptor can activate the hunger and satiety pathways, including the pathway that induces melanosin and reduces appetite.
Drug interaction Due to the mechanism of action of lorcaserin and the theoretical possibility of serotonin syndrome, lorcaserin and may affect the serotonergic neurotransmitter system should be used with extra caution when combined, including triptane monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, selective serotonin and norepinephrine reuptake inhibitors, tricyclic antidepressants, bupropion, dextromethorphan, lithium tramadol and St. John's wort. In addition, caution should be taken when this product is combined with CYP2D6 substrates, because this product can increase the exposure of such drugs.
safety lorcaserin has good tolerance and safety. lorcaserin is used in non-diabetic patients. the most common adverse reactions include headache, dizziness, fatigue, nausea, dry mouth and constipation. This product is used in diabetic patients. Common adverse reactions include hypoglycemia, headache, back pain, cough and fatigue. The study found that lorcaselin and placebo had similar rates of serious adverse reactions, and lorcaselin did not increase the incidence of valvular heart disease. The incidence of depression and depression after lorcaselin treatment is relatively low. Studies have shown that the proportion of depression caused by lorcaselin 10mgbid,10mgqd and placebo is 1.9%,1.1% and 1.8% respectively. The incidence of depression is 0.6%,0.9% and 0.9% respectively. The proportion of suicidal thoughts is 0.9%,0.6% and 0.7% respectively.
This product is grade X for pregnancy and is prohibited for pregnant women; it is not known whether this product is secreted by milk. Breast-feeding women need to weigh the pros and cons when using this drug; this product is not recommended for children.
use diet pills. Lorcaserin can be used to treat opioid use disorders (OUD).
toxic substance data information provided by: pubchem.ncbi.nlm.nih.gov (external link)
Last Update：2024-04-10 22:29:15
APD 356
Supplier List
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Lorcaserin Monomer Visit Supplier Webpage Request for quotation
CAS: 616202-92-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Lorcaserin Request for quotation
CAS: 616202-92-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: LORCASERIN Request for quotation
CAS: 616202-92-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Lorcaserin Monomer Visit Supplier Webpage Request for quotation
CAS: 616202-92-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Lorcaserin Request for quotation
CAS: 616202-92-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: LORCASERIN Request for quotation
CAS: 616202-92-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
View History
APD 356
  • Home
  • Product Category

© 2015, 2023 ChemBK.com All Rights Reserved | Build: 20230617001